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Category: Manuscript

Manuscript

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21

Hussain, A., Voisin, V., Poon, S., Karamboulas, C., Bui, N., Meens, J., Dmytryshyn, J., Ho, V. W., Tang, K. H., Paterson, J., Clarke, B. A., Bernardini, M. Q., Bader, G. …

Manuscript

PI3K inhibitors curtail MYC-dependent mutant p53 gain-of-function in head and neck squamous cell carcinoma.

Ganci F, Pulito C, Valsoni S, Sacconi A, Turco C, Vahabi M, Manciocco V, Mazza EMC, Meens J, Karamboulas C, Nichols AC, Covello R, Pellini R, Spriano G, Sanguineti G, …

Manuscript

N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.

Sinha A, Hussain A, Ignatchenko V, Ignatchenko A, Tang KH, Ho VWH, Neel BG, Clarke B, Bernardini MQ, Ailles L, Kislinger T. Cell Syst. 2019 Apr 24;8(4):345-351.e4. doi: 10.1016/j.cels.2019.03.011. Epub 2019 …

Manuscript

A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC. Int J Cancer. 2019 Oct …

Manuscript

Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma.

Karamboulas C, Bruce JP, Hope AJ, Meens J, Huang SH, Erdmann N, Hyatt E, Pereira K, Goldstein DP, Weinreb I, Su J, O’Sullivan B, Tiedemann R, Liu FF, Pugh TJ, …

Manuscript

Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

Teichman J, Dodbiba L, Thai H, Fleet A, Morey T, Liu L, McGregor M, Cheng D, Chen Z, Darling G, Brhane Y, Song Y, Espin-Garcia O, Xu W, Girgis H, …

Manuscript

Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.

Principe S, Mejia-Guerrero S, Ignatchenko V, Sinha A, Ignatchenko A, Shi W, Pereira K, Su S, Huang SH, O’Sullivan B, Xu W, Goldstein DP, Weinreb I, Ailles L, Liu FF, Kislinger …

Manuscript

A TRACER 3D Co-Culture tumour model for head and neck cancer.

Young M, Rodenhizer D, Dean T, D’Arcangelo E, Xu B, Ailles L, McGuigan AP. Biomaterials. 2018 May;164:54-69. doi: 10.1016/j.biomaterials.2018.01.038. Epub 2018 Feb 19.PMID: 29490260

Manuscript

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.

Lobo NC, Gedye C, Apostoli AJ, Brown KR, Paterson J, Stickle N, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Moffat J, Jewett MA, Ailles …

Manuscript

Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma.

Gedye C, Sirskyj D, Lobo NC, Meens J, Hyatt E, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Jewett MA, Ailles LE. Sci Rep. …

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