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Author: Laurie Ailles

Manuscript

Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21

Hussain, A., Voisin, V., Poon, S., Karamboulas, C., Bui, N., Meens, J., Dmytryshyn, J., Ho, V. W., Tang, K. H., Paterson, J., Clarke, B. A., Bernardini, M. Q., Bader, G. …

Manuscript

PI3K inhibitors curtail MYC-dependent mutant p53 gain-of-function in head and neck squamous cell carcinoma.

Ganci F, Pulito C, Valsoni S, Sacconi A, Turco C, Vahabi M, Manciocco V, Mazza EMC, Meens J, Karamboulas C, Nichols AC, Covello R, Pellini R, Spriano G, Sanguineti G, …

Manuscript

N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.

Sinha A, Hussain A, Ignatchenko V, Ignatchenko A, Tang KH, Ho VWH, Neel BG, Clarke B, Bernardini MQ, Ailles L, Kislinger T. Cell Syst. 2019 Apr 24;8(4):345-351.e4. doi: 10.1016/j.cels.2019.03.011. Epub 2019 …

Commentary

Patient-derived xenografts: a promising resource for preclinical cancer research.

Karamboulas C, Ailles L. Mol Cell Oncol. 2019 Jan 8;6(1):1558684. doi: 10.1080/23723556.2018.1558684. eCollection 2019.PMID: 30788424 

Manuscript

A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC. Int J Cancer. 2019 Oct …

Manuscript

Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma.

Karamboulas C, Bruce JP, Hope AJ, Meens J, Huang SH, Erdmann N, Hyatt E, Pereira K, Goldstein DP, Weinreb I, Su J, O’Sullivan B, Tiedemann R, Liu FF, Pugh TJ, …

Manuscript

Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

Teichman J, Dodbiba L, Thai H, Fleet A, Morey T, Liu L, McGregor M, Cheng D, Chen Z, Darling G, Brhane Y, Song Y, Espin-Garcia O, Xu W, Girgis H, …

Manuscript

Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.

Principe S, Mejia-Guerrero S, Ignatchenko V, Sinha A, Ignatchenko A, Shi W, Pereira K, Su S, Huang SH, O’Sullivan B, Xu W, Goldstein DP, Weinreb I, Ailles L, Liu FF, Kislinger …

Manuscript

A TRACER 3D Co-Culture tumour model for head and neck cancer.

Young M, Rodenhizer D, Dean T, D’Arcangelo E, Xu B, Ailles L, McGuigan AP. Biomaterials. 2018 May;164:54-69. doi: 10.1016/j.biomaterials.2018.01.038. Epub 2018 Feb 19.PMID: 29490260

Methods

High Throughput Flow Cytometry for Cell Surface Profiling.

High Throughput Flow Cytometry for Cell Surface Profiling. Paterson J, Ailles LE. Methods Mol Biol. 2018;1678:111-138. doi: 10.1007/978-1-4939-7346-0_7.PMID: 29071678

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